Association of Multiple Myeloma and Giant Cell Arteritis – A Case Report

  • Rui Marques Osório Internal Medicine Department, Hospital de Faro, Centro Hospitalar do Algarve, Faro, Portugal
  • Sérgio Pina Internal Medicine Department, Hospital de Faro, Centro Hospitalar do Algarve, Faro, Portugal
  • Teresa Salero Internal Medicine Department, Hospital de Faro, Centro Hospitalar do Algarve, Faro, Portugal
  • Margarida Viana Coelho Internal Medicine Department, Hospital de Faro, Centro Hospitalar do Algarve, Faro, Portugal
  • Domingos Sousa Internal Medicine Department, Hospital de Faro, Centro Hospitalar do Algarve, Faro, Portugal
  • Catarina Mendonça Internal Medicine Department, Hospital de Faro, Centro Hospitalar do Algarve, Faro, Portugal

Keywords

Giant cell arteritis, multiple myeloma, autoimmunity

Abstract

Autoimmune diseases (AID) have been associated with a variety of lymphoproliferative disorders. Multiple myeloma (MM), one of the most common haematologic malignancies characterized by clonal proliferation of bone marrow plasma cells, has been associated with a range of autoimmune disorders. In this report, we described a case study of a patient admitted to our Internal Medicine Department for a bone marrow biopsy and myelogram due to a monoclonal peak observed by his general practitioner. However, at admission he presented typical giant cell arteritis (GCA) complaints, suggesting the coexistence of both diseases. The possible pathogenesis, as found in the literature, explaining the association will be discussed.

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References

  • Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 2014;15(12):e538–548.

  • Keung YK, Yung C, Wong JW, Shah F, Cobos E. Association of temporal arteritis, retinal vasculitis, and xanthomatosis with multiple myeloma: case report and literature review. Mayo Clin Proc 1998;73(7):657–660.

  • Lindqvist EK, Landgren O, Lund SH, Turesson I, Hultcrantz M, Goldin L, et al. History of autoimmune disease is associated with impaired survival in multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based study. Ann Hematol 2017;96(2):261–269.

  • Hunder GG, Bloch DA, Michel BA, Stevens MB, Calabrese LH, Edworthy SM et al. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 1990;33(8):1122-1128.

  • Hellmich B, Agueda A, Monti S, Buttgereit F, De Boysson H, Brouwer E, et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis Epub 2019 Jul 03. doi: 10.1136/annrheumdis-2019-215672.

  • Gupta M, Malik S, Kalra R, Sharma N, Singh S, Gupta V, et al. Etiological profile of plasmacytosis on bone marrow aspirates. Dicle Med J/Dicle Tip Derg2016;43(1):1–4.

  • Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon; 2008, p. 442.

  • Ávila AM, Giralt S. Autoimmune disorders and multiple myeloma - two illustrative case reports and a literature review. Rev Colomb Cancerol 2018;22(2):76–83.

  • Finn BC, Young P, Silva ED, Bruetman JE, Bottaro FJ, Venditti JE, et al. Mieloma multiple y arteritis de celulas gigantes sin amiloidosis. Medicina (B Aires) 2006;66(6):555–557.
  • Published: 2020-01-07

    Issue: Vol 7 No 1 (view)

    Section: Articles

    How to cite:
    Osório, R., Pina, S., Salero, T., Coelho, M., Sousa, D., & Mendonça, C. (2020). Association of Multiple Myeloma and Giant Cell Arteritis – A Case Report. European Journal of Case Reports in Internal Medicine, 7(1). https://doi.org/https://doi.org/10.12890/2020_001360