Hypercalcemia and Extensive Chest Metastasis of Vulvar Squamous Cell Carcinoma
  • Ernestina Natália Mota
    Serviço de Medicina 2, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
  • Isabel Paulos Mesquita
    Serviço de Medicina 2, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
  • Carlos Pires
    Serviço de Medicina 2, Hospital Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
  • Rui M.M. Victorino
    Serviço de Medicina, Hospital Santa Maria, Faculdade de Medicina de Lisboa, Centro Hospitalar Lisbona Norte, Lisbon, Portugal

Keywords

Squamous cell carcinoma of the vulva, paraneoplastic hypercalcemia, pulmonary metastasis of vulvar squamous cell carcinoma

Abstract

A 73-year-old woman with a diagnosis of vulvar carcinoma submitted to curative surgery 5 years previously, presented to the emergency department with prostration and vulvar haemorrhage. Although the gynaecological examination was unremarkable, she had a mass in the left chest wall and hypercalcemia. A CT scan of the thorax revealed a voluminous left hemithorax mass invading the mediastinum, lung, pleura and chest wall. Ultrasound-guided biopsy of the mass showed infiltration by a well-differentiated keratinizing squamous cell carcinoma (SCC). This case report describes an extremely rare metastatic pattern in vulvar SCC concomitant with paraneoplastic hypercalcemia.

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References

  • Meelapkij P, Suprasert P, Baisai O. Treatment outcomes of patients with squamous cell carcinoma of the vulva: the largest series from a tertiary care hospital.Obstet Gynecol Int 2018;2018:4723167.

  • Buchanan T, Mutch D. Squamous cell carcinoma of the vulva: a review of present management and future considerations. Expert Rev Anticancer Ther 2019;19:43–50.

  • Agrawal A, Wood KA, Giede CK, Chibbar R. A case of kidney metastasis in vulvar squamous cell carcinoma: a case report and review of literature. Case Rep Clin Med 2013;2:306–309.

  • Prieske K, Haeringer N, Grimm D, Trillsch F, Eulenburg C, Burandt E, et al. Patterns of distant metastasis in vulvar cancer. Gynecol Oncol2016;142:427–434.

  • Sukur, YE, Gözüküçük M, Berker B. Hypercalcemia associated with early recurrence of vulvar cancer. Arch Gynecol Obstet 2010;281:117–118.

  • Pereira TC, Share SM, Magalhães AV, Silverman JF. Silverman JF. Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases. Appl Immunohistochem Mol Morphol 2011;19:10–14.

  • Milovanovic IS, Stjepanovic M, Mitrovic D, Mitrovic D. Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: an autopsy study. Ann Thorac Med 2017;12:191–198.

  • Alkatout I, Schubert M, Garbrecht N, Weigel MT, Jonat W, Mundhenke C, et al. Vulvar cancer: epidemiology, clinical presentation and management options. Int J Womens Health 2015;7:305–313.

  • Malangone S, Campen CJ. Hypercalcemia of malignancy. J Adv Pract Oncol 2015;6:586–592.

  • Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clinic Proc 2010;85:838–854.
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    Published: 2019-09-02
    Issue: Vol 6 No 9 (view)


    How to cite:
    1.
    Mota EN, Mesquita IP, Pires C, Victorino RM. Hypercalcemia and Extensive Chest Metastasis of Vulvar Squamous Cell Carcinoma. EJCRIM 2019;6 doi:10.12890/2019_001218.