Systemic Amyloidosis with Renal Failure: A Challenging Diagnosis of SAPHO Syndrome

  • Cristina Pires Correia Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • António Martins Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • Jorge Oliveira Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • Sérgio Andrade Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • Jorge Almeida Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
DOI: https://doi.org/10.12890/2019_001087

Keywords

AA amyloidosis, SAPHO syndrome, hidradenitis suppurativa

Abstract

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare, unrecognized and chronic inflammatory disorder characterized by distinct cutaneous and osteoarticular manifestations. Renal complications are uncommon. We describe the unusual case of a patient with severe refractory and chronic hidradenitis suppurativa (HS) that progressed to chronic renal failure due to secondary amyloidosis, presenting with mandibular pain and renal failure. The challenging diagnosis of SAPHO syndrome was made. The purpose of this case report is to emphasize the need for vigilance, timely recognition and multidisciplinary treatment. The fundamental management of AA amyloidosis and SAPHO syndrome requires an individualized approach with control of the underlying inflammatory disease.

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References

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    • Published: 2019-03-27

    Issue: Vol 6 No 4 (view)

    Section: Articles

    How to cite:
    1.
    Correia CP, Martins A, Oliveira J, Andrade S, Almeida J. Systemic Amyloidosis with Renal Failure: A Challenging Diagnosis of SAPHO Syndrome. EJCRIM 2019;6 doi:10.12890/2019_001087.