E-mail this Article (login required)
E-mail the Author (login required)
Post a Comment (login required)
Light-Chain Deposition Disease with Prominent Hepatic Involvement
Ana Vaz Cristino, Carmen Tavares Pais, Renata Violante Silva, Paulo Carrola
European Journal of Case Reports in Internal Medicine - © EFIM


Light-chain deposition disease (LCDD) is a rare monoclonal gammopathy that involves the deposition of light chains (LC) in multiple organs, leading to progressive dysfunction. The kidney is usually the most affected organ and responsible for the initial clinical manifestations. We present the case of a patient with LCDD with prominent liver involvement (marked cholestasis, hepatomegaly and portal hypertension) but with no evidence of coexisting lymphoproliferative disorder.


Light-chain deposition; monoclonal; plasma cell

  1. Merlini G, Palladini G. Enlightening light chain deposition disease. Blood 2015;126:2770–2771.
  2. Costa S, Dias P, Gaspar E, Cipriano M, Parente F, Lourenço A, et al. Doença de deposição de cadeias leves com atingimento hepático predominante: a propósito de um caso clínico. Rev Port Med Int 2006;13:172–178.
  3. Kumar P, Sandhya V, Venkatakrishnan L, Krishnaveni J, Mohanakrishnan A, Nirmala V. Light chain deposition disease presenting as cholestatic jaundice: a case report. Oman Med J 2012;27:56–59.
  4. Hall C, Peat D. Light chain deposit disease: a frequent cause of diagnostic difficulty. Nephrol Dial Transplant 2001;16:1939–1941.

© EFIM Copyright 2016