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Two Faces of the Same Coin: A Case Report of Antiphospholipid Syndrome Nephropathy
Sofia Homem de Melo Marques, Hugo André Nascimiento Ferreira, Ana Teresa Pires de Morais Nunes, Roberto Nicolau Pestana Silva, Susana Maria Moreira Sampaio Norton
European Journal of Case Reports in Internal Medicine - © EFIM


Antiphospholipid syndrome (APS) is an autoimmune disease which can be primary or secondary to other autoimmune conditions and is defined by the occurrence of arterial or venous thrombosis, or pregnancy morbidity associated with persistently positive antiphospholipid antibodies (aPLA). The kidney may be affected by thrombosis at any level of its vasculature. When small vessels are involved, this results in thrombotic microangiopathy (TMA), which can manifest as either acute vaso-occlusive or chronic vascular lesions in glomeruli, arterioles and interlobular arteries. We report the case of 26-year-old man, with a previous medical history suggestive of APS, who was found to have a small elevation in serum creatinine. A kidney biopsy was performed and revealed features of chronic TMA. Anticoagulation was begun and kidney function remained stable. However, one year later, upon suspension of anticoagulation, the patient developed acute kidney injury and a second kidney biopsy showed acute TMA. This case describes different manifestations of antiphospholipid syndrome nephropathy (APSN) and highlights the importance of anticoagulation for thrombosis prevention.


Antiphospholipid syndrome, Antiphospholipid syndrome nephropathy, kidney biopsy, thrombotic microangiopathy

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