Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis
  • Amitesh Aggarwal
    Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India
  • Mukul P Agarwal
    Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India
  • Surendra Rajpal
    Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India
  • Vineeta V Batra
    Department of Pathology, Govind Ballabh Pant hospital, New Delhi, India
  • Ankit Kumar Sahu
    Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India

Abstract

We present a rare case of a 23-year-old male incidentally detected with hepatitis B virus (HBV) infectionpresenting with features suggestive of HBV-associated nephropathy. A renal biopsy specimen suggested a mesangioproliferative glomerulonephritis with a full-house pattern on immunoflourescence consistent with a diagnosis of diffuse lupus nephritis. Glomerular HbeAg and HbsAg antigens were not detectable by immunofluorescence. Antiviral therapy was instituted to suppressviral replication, thereby leading to clinical and virological remission, including that of the glomerulonephritis, without the need for additional immunosuppressant therapy. This case depicts the uniqueness of the presentation of the two conditionsmimicking each other, the strategy adopted to prevent the activation of viral replication and the achievement of clinical remission.

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    Published: 2014-04-15
    Issue: Vol. 1 (2014) (view)

    How to cite:
    1.
    Aggarwal A, Agarwal MP, Rajpal S, Batra VV, Sahu AK. Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis. EJCRIM 2014;1 doi:10.12890/2014_000040.

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