Keywords
Autoimmune hepatitis, cirrhosis, drug-induced liver injury, interferon-beta, multiple sclerosis.
Abstract
Autoimmune hepatitis (AIH) is a disease of unknown aetiology with drug-induced AIH being the most complex and not fully understood type. We present the case of a 57-year-old female patient with acute icteric hepatitis after interferon-beta-1b (IFN?-1b) administration for multiple sclerosis (MS). Based on liver autoimmune serology, histology and appropriate exclusion of other liver diseases, a diagnosis of AIH-related cirrhosis was established. Following discontinuation of IFN?-1b, a complete resolution of biochemical activity indices was observed and the patient remained untreated on her own decision. However, 3 years later, after a course of intravenous methylprednisolone for MS, a new acute transaminase flare was recorded which subsided again spontaneously after 3 weeks. Liver biopsy and elastography showed significant fibrosis regression (F2 fibrosis). To our knowledge, this is the first report showing spontaneous cirrhosis regression in an IFN?-1b-induced AIH-like syndrome following drug withdrawal, suggesting that cirrhosis might be reversible if the offending fibrogenic stimulus is withdrawn.
References
Views: 1158
HTML downloads: 392
PDF downloads: 479
Cover Letter downloads: 0
Figure 1 downloads: 0
Response letter downloads: 0
Clean revised version downloads: 0
Published:
2016-06-07
Issue:
Vol. 3 No. 4
(view)