Keywords
niacin, nicotinic acid, nicotinamide, vitamin B3, Friedreich’s ataxia, toxicity, intoxication, adverse effect
Abstract
A 40-year old woman, previously known for Friedreich’s ataxia, presented with shock, profound lactic acidosis and hepatic failure after ingestion of a high dose of nicotinamide, the amide form of vitamin B3. On her own initiative, she was taking up to 4.4 g per day of nicotinamide, after having learned the results of a phase 2 study suggesting a potential benefit in Friedreich’s ataxia. The outcome was good with supportive care and withdrawal of nicotinamide.
References
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Published:
2015-06-25
Issue:
Vol. 2 No. 3 (2015)
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