Superior Vena Cava Syndrome: An Uncommon Presentation of a Rare Colon Carcinoma Metastasis
  • Sofia Gomes Brazao
    Internal Medicine, Centro Hospitalar e Universitário de Coimbra - Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Diana Silva
    Internal Medicine, Centro Hospitalar e Universitário de Coimbra - Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Joana Duarte
    Internal Medicine, Centro Hospitalar e Universitário de Coimbra - Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • José Bernardes
    Internal Medicine, Centro Hospitalar e Universitário de Coimbra - Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Manuel Teixeira Verissimo
    Internal Medicine, Centro Hospitalar e Universitário de Coimbra - Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Armando Carvalho
    Internal Medicine, Centro Hospitalar e Universitário de Coimbra - Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Keywords

Colon cancer, metastasis, mediastinal mass, subcutaneous nodules

Abstract

Introduction:Superior vena cava (SVC) syndrome is caused by obstruction of the superior vena cava due to vascular compression by a mass or intrinsic obstruction. The authors describe SVC syndrome caused by an isolated metastatic mediastinal mass from a resected primary colon carcinoma.
Case Report: An 81-year-old woman was referred to the hospital with swelling of the neck and upper left limb, dysphonia and dysphagia, associated with an involuntary weight loss of 16 kg. Mediastinal metastasis of colon adenocarcinoma was found, causing the SVC syndrome. The mass was unresectable and the patient was referred to palliative radiotherapy.
Discussion: Only 12 cases of mediastinal metastasis from colorectal cancer have been reported in the English literature.
Conclusion: As a rare manifestation of colorectal cancer, the presented case highlights the need for clinicians to be aware of rare metastases at the time of diagnosis.

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References

  • Wilson LD, Detterbeck FC, Yahalom J. Clinical practice. Superior vena cava syndrome with malignant causes. N Engl J Med 2007;356(18):1862–1869.

  • Hashimi Y, Dholakia S. Facial cutaneous metastasis of colorectal adenocarcinoma. BMJ Case Rep 2013;2013. pii: bcr2013009875.

  • Vetto JT, Cohen AM. Isolated spread of hepatic metastatic disease to a mediastinal lymph node. Report of a case and review of pertinent anatomy and literature. Dis Colon Rectum 1991;34:1128–1130.

  • Kuba H, Sato N, Uchiyama A, et al. Mediastinal lymph node metastasis of colon cancer: report of a case. Surg Today 1999;29:375–377.

  • Musullam KM, Taher AT, Tawil AN, Chakhachiro ZI, Habbal MZ, Shamseddine AI. Solitary mediastinal lymph node metastasis in rectosigmoid carcinoma: a case report. Cases J 2008;1:69.

  • Yava? Ö, Eren Ö, Artaç M, Börüban C, Genç M. A case of superior vena cava syndrome caused by colon cancer treated with bevacizumab combination chemotherapy. Turkish Journal of Cancer 2009;39(3):115–116.

  • Sano A, Murakawa T, Morota T, Nakajima J. Resection of a posterior mediastinal metastasis of colon cancer. Ann Thorac Surg 2011;92:353–354.

  • Iwata T, Chung K, Hanada S, et al. Solitary bulky mediastinal lymph node metastasis from colon cancer. Ann Thorac Cardiovasc Surg 2013;19:313–315.

  • Matsuda Y, Yano M, Miyoshi N, et al. Solitary mediastinal lymph node recurrence after curative resection of colon cancer. World J Gastrointest Surg 2014;6:164–168.

  • El-Halabi MM, Chaaban SA, Meouchy J, Page S, Salyers WJ Jr. Colon cancer metastasis to mediastinal lymph nodes without liver or lung involvement: a case report. Oncol Lett 2014;8:2221–2224.

  • Shirakawa Y, Noma K, Koujima T, et al. Prone-position thoracoscopic resection of posterior mediastinal lymph node metastasis from rectal cancer. World J Surg Oncol 2015;13:45.

  • Rodríguez-López J, Toro-Bahamonde A, Santiago-Méndez R, González-Cancel I, Vélez-Cortés H. An unusual case of colorectal adenocarcinoma presenting as an anterior mediastinal mass. Clin Colorectal Cancer 2018;17:115–119.

  • Toda K, Kawada K, Sakai Y, Izum H. Metachronous mediastinal lymph node metastasis from ascending colon cancer: a case report and literature review. Int J Surg Case Rep 2017;41:336–339.

  • August DA, Sugarbaker PH, Schneider PD. Lymphatic dissemination of hepatic metastases: implications for the follow-up and treatment of patients with colorectal cancer. Cancer 1985;55:1490.

  • McLoud TC, Kalisher L, Stark P, Greene R. Intrathoracic lymph node metastases from extrathoracic neoplasms. AJR Am J Roentgenol 1978;131:403–407.

  • Juanpere S. A diagnostic approach to the mediastinal masses. Insights Imaging2013;4:29–52.

  • Ribeiro Gomes J, Belotto M, D’Alpino Peixoto R. The role of surgery for unusual sites of metastases from colorectal cancer: a review of the literature. Eur J Surg Oncol 2017;43:15–19.
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    Published: 2019-05-15
    Issue: Vol 6 No 5 (view)


    How to cite:
    1.
    Brazao SG, Silva D, Duarte J, Bernardes J, Verissimo MT, Carvalho A. Superior Vena Cava Syndrome: An Uncommon Presentation of a Rare Colon Carcinoma Metastasis. EJCRIM 2019;6 doi:10.12890/2019_001115.

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