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When the Treatment is the Cause: Disseminated Bacille Calmette–Guérin Infection
Ana Teresa Marques Afonso, Montserrat Rodríguez Framil, Joaquín Sánchez Leira, Néstor Vázquez Agra, Federico García-Rodeja Arias
2020-06-03

Bacille Calmette–Guérin (BCG) administration for superficial bladder cancer is a well-tolerated and very effective therapy. However, unpredictable systemic complications may occur on rare occasions. We present the case of a patient who attended for consultation because of fever, asthenia and weight loss following BCG immunotherapy. The clinical response to treatment and computed tomography scanning were key to diagnosis.

Beware of Drug Interactions Treating Iatrogenic Mycobacterium bovis Endocarditis from Intravesical BCG Instillation
Francesca Curri, Andrea Da Porto, Viviana Casarsa, Daria Albini, Giorgio Minen, Leonardo Alberto Sechi
2021-03-10

We report a case of mechanical mitral valve endocarditis associated with miliary disseminated bacillus Calmette-Guerin (BCG) infection following intravesical instillations for minimally invasive bladder cancer in a 65-year-old man. The diagnosis was established by echocardiographic evidence of vegetation on the prosthetic mitral valve, miliary lesions in the lungs and evidence of bloodstream infection sustained by Mycobacterium. We successfully treated the patient with the classical regimen of quadruple antituberculous therapy.

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