Haemophagocytic Syndrome in a 19-Year-Old Male with Plasmodium falciparum Malaria

  • Rembert Mertens Department of Internal Medicine and Infectious Diseases, Universitair Ziekenhuis Brussel, Brussels, Belgium
  • Sabine D Allard Department of Internal Medicine and Infectious Diseases, Universitair Ziekenhuis Brussel, Brussels, Belgium
  • Lucie Seyler Department of Internal Medicine and Infectious Diseases, Universitair Ziekenhuis Brussel, Brussels, Belgium
  • Kristin Jochmans Laboratory of Hematology, Universitair Ziekenhuis Brussel, Brussels, Belgium
  • Patrick Lacor Department of Internal Medicine and Infectious Diseases, Universitair Ziekenhuis Brussel, Brussels, Belgium

Abstract

Objectives: Infectious agents triggering haemophagocyticlymphohistiocytosis (HLH) primarily involve the herpes virus group. We report a case of HLH precipitated by Plasmodium falciparum.
Materials and methods: Clinical and laboratory findings in a patient presenting with fever were collected. After confirmation of acute malaria, anti-malarial treatment was administered.
Results: Despite initial favourable evolution, the patient developed fever again together with a worsening of the haematological parameters and increased ferritin levels. A bone marrow biopsy confirmed the diagnosis of HLH.
Conclusion: This case illustrates that HLH should be considered in the differential diagnosis of acute malaria in patients with persisting fever and pancytopenia.

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References

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Zhang K, Filipovich AH, Johnson J, Marsh RA, Villanueva J. Hemophagocytic lymphohistiocytosis, familial, in Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Stephens K (eds) GeneReviews. Seattle, WA: University of Washington, 1993.

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Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis, Pediatr Blood Cancer 2007;48:124–131.

Published: 2014-06-20

Issue: Vol. 1 (2014) (view)

Section: Articles

How to cite:
1.
Mertens R, Allard SD, Seyler L, Jochmans K, Lacor P. Haemophagocytic Syndrome in a 19-Year-Old Male with Plasmodium falciparum Malaria. EJCRIM [Internet]. 2014Jun.20 [cited 2020Sep.26];1(1). Available from: https://ejcrim.com/index.php/EJCRIM/article/view/73

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