Nasal Skin Necrosis: A Very Rare Manifestation of Antiphospholipid Syndrome

  • Carolina Oliveira Ourique Internal Medicine Department, Centro Hospitalar de São João, Oporto
  • Inês Chora Internal Medicine Department, Centro Hospitalar de São João, Oporto
  • Susana Guimarães Anatomical Pathology Department, Centro Hospitalar de São João, Oporto
  • Sara Júlio Otorhinolaryngology Department, Centro Hospitalar de São João, Oporto
  • Paula Vaz-Marques Internal Medicine Department, Centro Hospitalar de São João, Oporto

Keywords

Cutaneous necrosis, antiphospholipid syndrome, cryoglobulinaemia

Abstract

A 23-year-old woman, a smoker and oral oestrogen user, presented with nasal necrosis. No other symptoms or local trauma were described. Relevant laboratory findings included complement consumption, positive lupus-anticoagulant assay, increased rheumatoid factor and positive cryoglobulins. Screening for autoimmune conditions, haematological malignancies and infectious diseases was negative. Histological examination of the nasal skin showed small vessel occlusion without vasculitis. Later, a second positive lupus-anticoagulant assay supported the diagnosis of antiphospholipid syndrome. The patient improved with glucocorticoids and anticoagulation. This case report describes an unusual manifestation of antiphospholipid syndrome in a patient with cryoglobulinaemia contributing to the thrombotic event and highlights the importance of recognizing these overlapping disorders.

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  • Published: 2017-03-27

    Issue: Vol. 4 No. 2 (view)

    Section: Articles

    How to cite:
    1.
    Ourique CO, Chora I, Guimarães S, Júlio S, Vaz-Marques P. Nasal Skin Necrosis: A Very Rare Manifestation of Antiphospholipid Syndrome. EJCRIM 2017;4 doi:10.12890/2016_000534.