A Case of Infectious Purpura Fulminans: An Unusual Organism and Method of Diagnosis
  • Pei Chia Eng
    Department of General Medicine, Kings College Hospital, London, United Kingdom
  • Catherine Bryant
    Department of General Medicine and Department of Clinical Gerontology, Kings College Hospital, London, United Kingdom
  • Stephen H.D. Jackson
    Department of General Medicine and Department of Clinical Gerontology, Kings College Hospital, London, United Kingdom

Abstract

Infectious purpura fulminans is a rapidly progressive skin necrosis that has a mortality rate of 30%1,2. Here, we describe a case of infectious purpura fulminans caused by Capnocytophaga, diagnosed by a blood film.

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References

  • Smith OP, White B. Infectious purpura fulminans: diagnosis and treatment, Br J Haematol 1999;104:202–207.
  • Christiansee CB, Berg RM, Plovsing RR, Moller K. Two cases of infectious purpura fulminans and septic shock caused by Capnocytophaga canimorsus transmitted from dogs, Scan J Infect Dis 2012;44:635–639.
  • Brenner DJ, Hollis DG, Fanning GR, Weaver RE. Capnocytophaga canimorsus sp. Nov (formerly CDC group DF-2), a cause of septicaemia following dog bite and C. cynodegmi sp Nov., cause of localized wound infection following dog bite, J Clin Microbiol 1989;27:231–235.
  • Kullberg BJ, Westendorp RG, Van’t Wout JW, Meinders AE. Purpura fulminans and symmetrical peripheral gangrene caused by Capnocytophaga canimorsus (formerly DF-2) septicaemia: a complication of dog bite, Medicine (Baltimore) 1991;70:287–292.
  • Dire DJ, Hogan DE, Riggs MW. A prospective evaluation of risk factors of infection from dog wounds, Acad Emerg Med 1994;258–266
  • Mirza I, Wolk J, Toth L, Rostenburg P, Kranwinkel R, Sieber SC. Waterhouse–Friderichsen syndrome secondary to Capnocytophaga canimorsus septicemia and demonstration of bacteria by peripheral blood smear, Arch Pathol Lab Med 2000;124:859–863
  • Risum M, Ellekvist P. Capnocytophaga canimorsus meningitis diagnosed by means of a 16S rRNA analysis, Ugeskr Laeger 2012:174:280–281.
  • Hayani O, Higginson LA, Toye B, Burwash IG. Man’s best friend? Infective endocarditis due to Capnocytophaga canimorsus, Can J Cardiol 2009;25:130–132.
  • Ciantar M, Spratt DA, Newman HN, Wilson M. Assessment of five culture media for growth and isolation of Capnocytophaga spp, Clin Microbiol Infect 2001;July:158–160.
  • Janda MJ, Graves MH, Lindquist D, Probert WS. Diagnosing Capnocytophaga canimorsus infections, Emerg Infect Dis 2006;12:340–342.
  • De Melo Olicerira MG, Abels S, Zbinden R, Bloemberg GV, Zbinden A. Accurate identification of fastidious Gram-negative rods: integration of both conventional phenotypic methods and 16S rRNA gene analysis, BMC Microbiol 2013;13:162.
  • Bone RC. Gram-negative sepsis: a dilemma of modern medicine, Clin Microbiol Rev 1993;6:57–68.
  • Munford RS. Severe sepsis and septic shock : role of gram-negative bacteremia, Annu Rev Pathol 2006;467–496.
  • Jolivet-Gougeon A, Sixou J-L, Tamanai-Shacoori Z, Bonnaure-Mallet M. Antimicrobial treatment of Capnocytophaga infections, Int J Antimicrob Agents 2007;29:367–373.
  • Lloret A, Egberink H, Addie D et al. Capnocytophaga canimorsus: ABCD guidelines on prevention and management, J Feline Med Surg 2013;15:588–590.
  • Wedel NI, Gorelick KJ, Saria EA, Weidler DJ, Blaschke TF. Pharmacokinetics and safety of antiendotoxin antibody E5 in normal subjects, Crit Care Med 1990;18:S212.
  • Zhou F, Peng Z, Murugan R, Kellum JA. Blood purification and mortality in sepsis: a meta-analysis of randomized trials, Crit Care Med 2013;41:2209–2220.

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    Published: 2014-04-24
    Issue: Vol. 1 (2014) (view)

    How to cite:
    1.
    Eng PC, Bryant C, Jackson SH. A Case of Infectious Purpura Fulminans: An Unusual Organism and Method of Diagnosis. EJCRIM 2014;1 doi:10.12890/2014_000048.