A Rare Presentation of Leptospirosis

  • Filipa Silva Internal Medicine Department, Centro Hospitalar de São João, Porto
  • Mariana Brandão Medical Oncology Department, Instituto Português de Oncologia, Porto
  • Afonso Esteves Internal Medicine Department, Centro Hospitalar de São João, Porto


leptospirosis, acute renal failure, nephrotic syndrome


Leptospirosis has a wide spectrum of clinical manifestations. Acute renal failure, an important complication, generally involves interstitial and tubular damage. We describe the case of a 42-year-old man who was admitted with fever, back pain and periorbital oedema. He had hypertension, thrombocytopenia, acute renal failure, hypoalbuminaemia, hypertriglyceridaemia and proteinuria >4.00 g/l. The renal biopsy showed mesangioproliferative glomerulonephritis. Due to the epidemiological context and clinical picture, ceftriaxone was started with rapid clinical improvement. Blood PCR for leptospira came back positive. The presentation of leptospirosis as nephrotic syndrome is rare and this diagnosis should be considered before performing a renal biopsy.



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Published: 2016-09-28

Issue: Vol. 3 No. 6 (view)

Section: Articles

How to cite:
Silva F, Brandão M, Esteves A. A Rare Presentation of Leptospirosis. EJCRIM [Internet]. 2016Sep.28 [cited 2020Sep.26];3(6). Available from: https://ejcrim.com/index.php/EJCRIM/article/view/447

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