A Rare Presentation of Leptospirosis

  • Filipa Silva Internal Medicine Department, Centro Hospitalar de São João, Porto
  • Mariana Brandão Medical Oncology Department, Instituto Português de Oncologia, Porto
  • Afonso Esteves Internal Medicine Department, Centro Hospitalar de São João, Porto

Keywords

leptospirosis, acute renal failure, nephrotic syndrome

Abstract

Leptospirosis has a wide spectrum of clinical manifestations. Acute renal failure, an important complication, generally involves interstitial and tubular damage. We describe the case of a 42-year-old man who was admitted with fever, back pain and periorbital oedema. He had hypertension, thrombocytopenia, acute renal failure, hypoalbuminaemia, hypertriglyceridaemia and proteinuria >4.00 g/l. The renal biopsy showed mesangioproliferative glomerulonephritis. Due to the epidemiological context and clinical picture, ceftriaxone was started with rapid clinical improvement. Blood PCR for leptospira came back positive. The presentation of leptospirosis as nephrotic syndrome is rare and this diagnosis should be considered before performing a renal biopsy.

VIEW THE ENTIRE ARTICLE

References

Daher Ede F, Abreu KL, da Silva Junior GB. Leptospirosis-associated acute kidney injury. J Bras Nefrol 2010;32:400–407.

Abdulkader RC, Silva MV. The kidney in leptospirosis. Pediatr Nephrol 2008;23:2111–2120.

Kshirsagar PP, Sonavane AD, Doshi AC, Teltumbde U, Mandalik S. Atypical presentation of leptospirosis. J Assoc Physicians India 2010;28:114–115.

Seyit K, Sezai V, Aytaç K, Osman E, Leyla K, Hamit B et al. A case of leptospirosis presenting with nephrotic syndrome, acute renal failure and thrombocytopenia. Istanbul Tip Fakultesi Dergisi Cilt 2009;2:25–28.

Visith S, Kearkiat P. Nephropathy in leptospirosis. J Postgrad Med 2005;51:184–188.

Becj L, Bomback A, Choi M, Holzman L, Mariani L et al. KDIGO Clinical Practice Guideline for Glomerulonephritis. Am J Kidney Dis 2013;62:403–441.

Published: 2016-09-28

Issue: Vol. 3 No. 6 (view)

Section: Articles

How to cite:
1.
Silva F, Brandão M, Esteves A. A Rare Presentation of Leptospirosis. EJCRIM [Internet]. 2016Sep.28 [cited 2020Sep.26];3(6). Available from: https://ejcrim.com/index.php/EJCRIM/article/view/447

Similar Articles

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)