Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

  • Yanet Parodis Lopez Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Nery Sablon Gonzalez Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Noel Lorenzo Villalba Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Rafael Camacho Galvan Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Jose Carlos Rodriguez Perez Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,

Keywords

Thrombotic microangiopathy, thrombotic thrombocytopenic purpura, prasugrel

Abstract

We report a case of a 64-year-old male who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease.

References

  • George JN, Leung LLK, Tirnauer JS. Drug-induced thrombotic microangiopathy. 2015 Uptodate. http://www.uptodate.com/contents/drug-induced-thrombotic-microangiopathy visited on 30/05/2016.

  • Al-Nouri ZL, Reese JA, Terrell DR, et al. Drug-induced thrombotic microangiopathy: a systematic review of published reports. Blood 2015;125:616-618.

  • Reese JA, Bougie DW, Curtis BR, et al. Drug-induced thrombotic microangiopathy: Experience of the Oklahoma Registry and the Blood Center of Wisconsin. Am J Hematol 2015;90:406-410.

  • Jacob S, Dunn BL, Qureshi ZP, et al. Ticlopidine, Clopidogrel and Prasugrel-Associated Thrombotic Thrombocytopenic Purpura: A 20-Year Review from the Southern Network on Adverse Reactions (SONAR). Semin Thromb Hemost 2012;38:845-853.

  • Zakarija A, Kwaan HC, Moake JL. Ticlopidine and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): Review of clinical, laboratory, epidemiological and pharmaco vigilance findings (1989–2008). Kidney Int 2009;75:S20-S24.
  • Published: 2016-07-27

    Issue: Vol 3 No 5 (view)

    Section: Articles

    How to cite:
    Lopez, Y., Gonzalez, N., Villalba, N., Galvan, R., & Perez, J. C. (2016). Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency. European Journal of Case Reports in Internal Medicine, 3(5). https://doi.org/https://doi.org/10.12890/2016_000446