Rapidly Progressive Bronchiectasis and Pulmonary Fibrosis in Yellow Nail Syndrome with Possible Association with Selective IgM Deficiency

  • Mohammad Abu-Abaa Internal Medicine, Capital Health Regional Medical Center, Trenton, NJ, USA
  • Mohamed Hassan Internal Medicine, Capital Health Regional Medical Center, Trenton, NJ, USA
  • Bashar Oudah Eisenhower Health, Rancho Mirage, CA, USA
  • Noor Al-Ameri Internal Medicine, Capital Health Regional Medical Center, Trenton, NJ, USA
DOI: https://doi.org/10.12890/2022_003577

Keywords

Yellow nail syndrome, bronchiectasis, pulmonary fibrosis, lymphoedema

Abstract

A 67-year-old man with a history of IgM deficiency and pulmonary fibrosis and bronchiectasis was admitted for management of worsening symptoms. Investigations revealed exudative pleural effusion with rapidly progressive bronchiectasis. Although a potential trigger of bronchiectasis and pulmonary fibrosis was not identified despite extensive work-up by several physicians in the past, a bedside observation of yellow dystrophic nails on all extremities revealed the diagnosis. This case report helps to remind clinicians of a rare medical disorder of still uncertain aetiology and no available cure. This case is consistent with a few previous case reports that suggest a potential association with selective immunoglobulin deficiency.

VIEW THE ENTIRE ARTICLE

References

  • Gupta S, Samra D, Yel L, Agrawal S. T and B cell deficiency associated with yellow nail syndrome. Scand J Immunol 2012 Mar;75(3):329–335. doi: 10.1111/j.1365-3083.2011.02653.x
  • Douri T. Yellow nails syndrome in two siblings. Dermatol Online J 2008 Sep 15;14(9):7. PMID: 19061589.
  • Maldonado F, Tazelaar HD, Wang C-W, Ryu JH. Yellow nail syndrome: analysis of 41 consecutive patients. Chest 2008;134:375–381.
  • Bokszezannin A, Levinson AL. Coexistent yellow nail syndrome and selective antibody deficiency.Ann Allergy Asthma Immunol 2003;91:496–500.
  • Vignes S, Baran R. Yellow nail syndrome: a review. Orphanet J Rare Dis 2017;12(1):42. https://doi.org/10.1186/s13023-017-0594-4
  • Woodfield G, Nisbet M, Jacob J, Mok W, Loebinger MR, Hansell DM, et al. Bronchiectasis in yellow nail syndrome. Respirology 2017 Jan;22(1):101–107.

    • Published: 2022-09-27

    Issue: 2022: Vol 9 No 9 (view)

    Section: Articles

    How to cite:
    1.
    Abu-Abaa M, Hassan M, Oudah B, Al-Ameri N. Rapidly Progressive Bronchiectasis and Pulmonary Fibrosis in Yellow Nail Syndrome with Possible Association with Selective IgM Deficiency. EJCRIM 2022;9 doi:10.12890/2022_003577.