Leishmaniasis Mimicking Lymphoma and/or Liver Cirrhosis
  • Luca Rossi
    University of Eastern Piedmont “A.Avogadro”, Novara, Italy
  • Monica Leutner
    University of Eastern Piedmont “A.Avogadro”, Novara, Italy
  • Daniele Sola
    University of Eastern Piedmont “A.Avogadro”, Novara, Italy
  • Ettore Bartoli
    University of Eastern Piedmont “A.Avogadro”, Novara, Italy

Abstract

A 76-year-old man was admitted to hospital with fever, weight loss, pancytopenia, hepatosplenomegaly and a double monoclonal component IgM-IgG-k, suggesting a diagnosis of myeloma. Bone marrow and liver biopsies disclosed the presence of Donovan bodies, and the titre of anti-Leishmania antibodies was extremely high. After treatment with liposomal amphotericin B, the titre of antibodies fell considerably, while monoclonal components, pancytopenia and clinical symptoms slowly disappeared. Polyclonal ?-globulins are made of innumerable monoclonal components, one of which can appear as a recognizable band and be misdiagnosed as myeloma when representing the high titre of an antibody directed towards a specific antigen.

VIEW THE ENTIRE ARTICLE

References

  • Hofbauer LC, Diebold J, Heufelder AE. Rheumatoid arthritis, neutropenia and splenomegaly: the Felty syndrome, Deutsch Med Wochenschr 1995;120:1689–1694.
  • Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, et al. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Lyon: IARC Press, 2008.
  • Dogan A, Attygalle AD, Kyriakou C. Angioimmunoblastic T-cell lymphoma, Br J Haematol 2003;121:681.
  • Lamy T, Loughran TP Jr (2003) Clinical features of large granular lymphocyte leukemia, Semin Hematol 2003;40:185.
  • Jaffe ES, Harris NL, Stein H, Vardiman JW. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues, Lyon: IARC Press, 2001.
  • Corti M, Palmero D. Mycobacterium avium complex infection in HIV/AIDS patients, Exp Rev Anti Infect Ther 2008;6:351–363.
  • Glynn MK, Lynn TV. Brucellosis. Veterinary medicine today: zoonosis update, J Am Vet Med Assoc 2008;233:900–908.
  • Chirinos JA, Garcia J, Alcaide ML, Toledo G, Baracco GJ, Lichtstein DM. Septic thrombophlebitis: diagnosis and management, Am J Cardiovasc Drugs 2006;6:9–14.
  • Mahto M, Balakrishnan P, Koner BC, Lali P, Mishra TK, Saxena A. Rare case of biclonal gammopathy. Int J Case Rep Images 2011;2:11–14 .
  • Gaeta GB, Gradoni L, Gramiccia M et al. Leishmaniosi viscerale in Italia. Epidemiologia, clinica, terapia, Rec Progr Med 1994;85:340–346.

    • Views: 749
    HTML downloads: 604
    PDF downloads: 423
    Figure 1 downloads: 0
    Figure 2 downloads: 0
    Figure 3 downloads: 0
    Figure 4 downloads: 0
    Table 1 downloads: 0

    Published: 2014-05-19
    Issue: Vol. 1 (2014) (view)

    How to cite:
    1.
    Rossi L, Leutner M, Sola D, Bartoli E. Leishmaniasis Mimicking Lymphoma and/or Liver Cirrhosis. EJCRIM 2014;1 doi:10.12890/2014_000032.

    Most read articles by the same author(s)