Leishmaniasis Mimicking Lymphoma and/or Liver Cirrhosis

  • Luca Rossi University of Eastern Piedmont “A.Avogadro”, Novara, Italy
  • Monica Leutner University of Eastern Piedmont “A.Avogadro”, Novara, Italy
  • Daniele Sola University of Eastern Piedmont “A.Avogadro”, Novara, Italy
  • Ettore Bartoli University of Eastern Piedmont “A.Avogadro”, Novara, Italy

Abstract

A 76-year-old man was admitted to hospital with fever, weight loss, pancytopenia, hepatosplenomegaly and a double monoclonal component IgM-IgG-k, suggesting a diagnosis of myeloma. Bone marrow and liver biopsies disclosed the presence of Donovan bodies, and the titre of anti-Leishmania antibodies was extremely high. After treatment with liposomal amphotericin B, the titre of antibodies fell considerably, while monoclonal components, pancytopenia and clinical symptoms slowly disappeared. Polyclonal ?-globulins are made of innumerable monoclonal components, one of which can appear as a recognizable band and be misdiagnosed as myeloma when representing the high titre of an antibody directed towards a specific antigen.

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  • Published: 2014-05-19

    Issue: Vol. 1 (2014) (view)

    Section: Articles

    How to cite:
    1.
    Rossi L, Leutner M, Sola D, Bartoli E. Leishmaniasis Mimicking Lymphoma and/or Liver Cirrhosis. EJCRIM 2014;1 doi:10.12890/2014_000032.

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