Haemophagocytic Lymphohistiocytosis as a Complication of Israeli Spotted Fever
  • Maria Margarida Andrade
    Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal
  • Ana Gorgulho
    Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal
  • Rita Tinoco Magalhães
    Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal
  • Rita Valadas
    Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal
  • Luís Miguel Pereira
    Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal
  • Sara Freire
    Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal
  • Diogo Cruz
    Internal Medicine Department, Hospital de Cascais Dr. José de Almeida, Alcabideche, Portugal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal

Keywords

Rickettsiosis, spotted fever, haemophagocytic, purpura fulminans, polyneuropathy

Abstract

Rickettsia spp. human infection is endemic in Portugal in the form of Mediterranean spotted fever caused by R. conorii subsp. conorii and Israeli spotted fever (ISF) caused by R. conorii subsp. israelensis. We describe a rare case of haemophagocytic lymphohistiocytosis (HLH) due to ISF, with atypical manifestations. We highlight the need for clinical suspicion for this diagnosis and the importance of timely intervention and support.

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References

  • Schram A, Berliner N. How I treat hemophagocytic lymphohistiocytosis in the adult patient. Blood 2015;125(19):2908–2914.
  • Pérez-de Pedro I, Macías-Vega N, Miranda-Candón I, Teresa Camps-García M. Infección grave por Rickettsia conorii asociada a síndrome hemofagocítico. Enferm Infecc Microbiol Clín 2008;26(9):597–598.
  • Wu JR, Yuan LX, Ma ZG, Chen XX, Gu L, Gao J. GDF15-mediated upregulation of ferroportin plays a key role in the development of hyperferritinemia in children with hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2013;60(6):940–945.
  • Cohen R, Babushkin F, Shapiro M, Uda M, Atiya-Nasagi Y, Klein D, et al. Two cases of Israeli spotted fever with purpura fulminans, Sharon District, Israel. Emerg Infect Dis 2018;24(5):835–840.
  • Evangelista T, Pimentel J, Luis M de L. Polirradiculonevrites agudas associadas à febre escaro-nodular [Acute polyradiculoneuritis associated with boutonneuse fever]. Acta Med Port 1994;7(7–8):437–439.

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    Published: 2022-01-17
    Issue: 2022: Vol 9 No 1 (view)

    How to cite:
    1.
    Andrade MM, Gorgulho A, Tinoco Magalhães R, Valadas R, Pereira LM, Freire S, Cruz D. Haemophagocytic Lymphohistiocytosis as a Complication of Israeli Spotted Fever. EJCRIM 2022;9 doi:10.12890/2021_003073.

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