Cardiac Sodium Channel Blockade Due to Antiepileptic Drug Combination
KeywordsSodium channel blockers, lacosamide, electrocardiogram
Drugs that inhibit voltage-dependent sodium channels are commonly used to treat epilepsy. Old and novel antiepileptic drugs are used either as monotherapy or in combination to control epilepsy. For a long time, carbamazepine has been used as the first choice for the treatment of simple and complex partial seizures. In the USA, lacosamide was approved in October 2008 as an adjunctive treatment for partial-onset seizures. We describe the effect of two sodium channel blockers on the heart of a patient with epilepsy.
Issue: 2021: Vol 8 No 10 (view)