Myasthenia Gravis Revealing Hodgkin’s Lymphoma

  • Jaouad Yousfi University Hospital of Mohammed VI, Department of Internal Medicine, Marrakesh, Morocco
  • Fatimazahra Bensalek University Hospital of Mohammed VI, Department of Internal Medicine, Marrakesh, Morocco
  • Mouna Zahlane University Hospital of Mohammed VI, Department of Internal Medicine, Marrakesh, Morocco
  • Laila Benjilali University Hospital of Mohammed VI, Department of Internal Medicine, Marrakesh, Morocco
  • Lamiaa Essaadouni University Hospital of Mohammed VI, Department of Internal Medicine, Marrakesh, Morocco

Keywords

Myasthenia gravis, paraneoplastic, Hodgkin's lymphoma

Abstract

Introduction: Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction.

Patient and methods: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma.

Results: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ?0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin’s lymphoma.

Conclusion: The association of lymphomas with myasthenia gravis has been rarely reported.

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References

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  • Published: 2021-03-12

    Issue: Vol 8 No 3 (view)

    Section: Articles

    How to cite:
    1.
    Yousfi J, Bensalek F, Zahlane M, Benjilali L, Essaadouni L. Myasthenia Gravis Revealing Hodgkin’s Lymphoma. EJCRIM 2021;8 doi:10.12890/2021_2375.

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