Hypercalcaemia: An Extremely Rare Presentation of Hepatosplenic T-Cell Lymphoma

  • Sara Almeida Ramalho Internal Medicine Department, Hospital Garcia de Orta, Almada, Portugal
  • Francisca Abecasis Internal Medicine Department, Hospital Garcia de Orta, Almada, Portugal
  • Letícia Santos Internal Medicine Department, Hospital Garcia de Orta, Almada, Portugal
  • Vanessa Leite
  • Diogo Gonçalves Pathology Department, Hospital Garcia de Orta, Almada, Portugal
  • Inês Pintassilgo Internal Medicine Department, Hospital Garcia de Orta, Almada, Portugal
  • Ana Luisa Broa Internal Medicine Department, Hospital Garcia de Orta, Almada, Portugal
DOI: https://doi.org/10.12890/2021_002360

Keywords

Hypercalcaemia, hepatosplenic lymphoma, hepatosplenomegaly, B symptoms, bone marrow

Abstract

Hypercalcaemia is a frequent finding in malignancies including lymphomas. However, there are no reports of hypercalcaemia in hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a rare and aggressive neoplasm which is usually difficult to diagnose. We present a case of HSTCL in which hypercalcaemia was the initial presentation.

VIEW THE ENTIRE ARTICLE

References

  • Yabe M, Miranda RN, Medeiros LJ. Hepatosplenic T-cell lymphoma: a review of clinicopathologic features, pathogenesis, and prognostic factors. Human Pathol 2018;74:5–16.
  • Vega F, Medeiros LJ, Gaulard P. Hepatosplenic and other ?? T-cell lymphomas. Am J Clin Pathol 2007;127(6):869–880.
  • Falchook GS, Vega F, Dang NH, Samaniego F, Rodriguez MA, Champlin RE, et al. Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment. Ann Oncol 2009;20(6):1080–1085.
  • Asonitis N, Angelousi A, Zafeiris C, Lambrou GI, Dontas I, Kassi E. Diagnosis, pathophysiology and management of hypercalcemia in malignancy: a review of the literature. Horm Metab Res 2019;51(12):770–778.
  • Weidmann E. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 2000; 14(6):991–997.

    • Published: 2021-02-25

    Issue: Vol 8 No 2 (view)

    Section: Articles

    How to cite:
    1.
    Almeida Ramalho S, Abecasis F, Santos L, Leite V, Gonçalves D, Pintassilgo I, Broa AL. Hypercalcaemia: An Extremely Rare Presentation of Hepatosplenic T-Cell Lymphoma. EJCRIM 2021;8 doi:10.12890/2021_002360.