Successful Use of a GLP-1 Receptor Agonist as Add-on Therapy to Sulfonylurea in the Treatment of KCNJ11 Neonatal Diabetes

  • Morten Hindsø Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
  • Christoffer Martinussen Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
  • Maria Saur Svane Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
  • Simon Veedfald Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • Birthe Gade-Rasmussen Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
  • Torben Hansen The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark
  • Sten Madsbad Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark

Keywords

Neonatal diabetes, KCNJ11, sulfonylurea, GLP-1

Abstract

Sulfonylurea monotherapy is the standard treatment for patients with the most common form of permanent neonatal diabetes, KCNJ11 neonatal diabetes, but it is not always sufficient. For the first time, we present a case of successful use of a GLP-1 receptor agonist as add-on therapy in the treatment of a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy. Good glycaemic control was maintained with a HbA1c level of 48 mmol/mol (6.5%) at the end of 26 months’ follow-up.

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  • Published: 2021-03-31

    Issue: Vol 8 No 3 (view)

    Section: Articles

    How to cite:
    1.
    Hindsø M, Martinussen C, Svane MS, Veedfald S, Gade-Rasmussen B, Hansen T, Madsbad S. Successful Use of a GLP-1 Receptor Agonist as Add-on Therapy to Sulfonylurea in the Treatment of KCNJ11 Neonatal Diabetes. EJCRIM 2021;8 doi:10.12890/2021_002352.