Congenital Inferior Vena Cava Agenesis with Ulceration and Deep Vein Thrombosis

  • Melanie Menning Department of Family Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
  • Mira Yousef College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA

Keywords

Inferior vena cava atresia, IVCA, ulcers, deep vein thrombus, DVT

Abstract

Objectives: This is one of the few case reports of congenital inferior vena cava atresia (IVCA) with extensive bilateral lower extremity ulcers.

Background: IVCA is a congenital anomaly characterized by poor venous return in the lower extremities with increased risk of deep vein thrombi (DVTs) and, rarely, non-healing ulcers.

Results: A 45-year-old woman with history significant for DVTs presented with extensive bilateral lower extremity ulcers, and a CT scan revealed congenital IVCA. Oedema management, DVT prevention, routine wound care and skin grafts resolved the ulcers.

Conclusion: Congenital venous abnormalities should be included in the differential diagnosis of multiple unprovoked DVTs and non-healing ulcers.

VIEW THE ENTIRE ARTICLE

References

  • Lambert M, Marboeuf P, Midulla M, Trillot N, Beregi JP, Mounier-Vehier C, et al. Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature. Vasc Med 2010;15(6):451–459.
  • Eifert S, Villavicencio JL, Kao T-C, Taute BM, Rich NM. Prevalence of deep venous anomalies in congenital vascular malformations of venous predominance. J Vasc Surg 2000;31(3):462–471.
  • Bianchi M, Giannini D, Balbarini A, Castiglioni MG. Congenital hypoplasia of the inferior vena cava and inherited thrombophilia: rare associated risk factors for idiopathic deep vein thrombosis. A case report. J Cardiovasc Med 2008;9(1):101–104.
  • Tufano A, López-Jiménez L, Bikdeli B, García-Bragado F, Mazzolai L, Amitrano M, et al. Inferior vena cava agenesis in patients with lower limb deep vein thrombosis in the RIETE registry. When and why to suspect. Int J Cardiol 2020;305:115–119.
  • Gupta A, Kumar S, Kothari SS. Congenital absence of infrarenal inferior vena cava and deep veins of the lower limbs: a case report. J Med Case Rep 2016;10(1):1–4.
  • Spentzouris G, Zandian A, Cesmebasi A, Kinsella CR, Muhleman M, Mirzayan N, et al. The clinical anatomy of the inferior vena cava: a review of common congenital anomalies and considerations for clinicians. Clin Anat 2014;27(8):1234–1243.
  • Sneed D, Hamdallah I, Sardi A. Absence of the retrohepatic inferior vena cava: what the surgeon should know. Am Surg 2005;71(6):502–504.
  • Moore KL, Persaud TVN. The cardiovascular system. In: The developing human: clinically oriented embryology. 6th ed. Philadelphia: WB Saunders; 1998, p. 351–358.
  • Muscianese L, Seese RR, Graham W, Williams JH. Congenital atresia of the inferior vena cava and antithrombin III deficiency in a young adult: compounding risk factors for deep vein thrombosis. BMJ Case Rep 2015;2015:bcr2014205729.
  • Raju S, Hollis K, Neglen P. Obstructive lesions of the inferior vena cava: clinical features and endovenous treatment. J Vasc Surg 2006;44(4):820–827.
  • Published: 2021-03-18

    Issue: Vol 8 No 3 (view)

    Section: Articles

    How to cite:
    1.
    Menning M, Yousef M. Congenital Inferior Vena Cava Agenesis with Ulceration and Deep Vein Thrombosis. EJCRIM 2021;8 doi:10.12890/2021_002312.