Hemophagocytic Lymphohistiocytosis Complicating Myelodysplasia
  • Geraldine Quintero-Platt
    Internal Medicine Department, Canary Islands University Hospital, La Laguna University, Tenerife, Canary Islands
  • Carima Belleyo-Belkasem
    Internal Medicine Department, Canary Islands University Hospital, La Laguna University, Tenerife, Canary Islands
  • Taida Martín-Santos
    Hematology Department, Canary Islands University Hospital, La Laguna University, Tenerife, Canary Islands
  • Onán Pérez-Hernández
    Internal Medicine Department, Canary Islands University Hospital, La Laguna University, Tenerife, Canary Islands
  • Emilio González-Reimers
    Internal Medicine Department, Canary Islands University Hospital, La Laguna University, Tenerife, Canary Islands

Abstract

We describe a 62-year-old patient with a 4-year history of myelodysplasia who later developedstriking features that included massive splenomegaly, rapidly evolving visual loss and a sensorimotor polyneuropathy. This led us to consider the diagnosisof haemophagocytic lymphohistiocytosis (HLH). Upon further investigation, we found that he fulfilled the necessarydiagnostic criteria for HLH, including the presence of haemophagocytosis of erythroid precursors on bone marrow smear.

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References

  • Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis, Pediatr Blood Cancer 2007;48:124–131.
  • Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. How I treat hemophagocytic lymphohistiocytosis, Blood 2011; 118:4041–4052.
  • Tsuji T, Yamasaki H, Arima N, Tsuda H. Hemophagocyic lymphohistiocytosis associated with myelodysplastic syndromes, Int J Hematol 2010;92:547–549.
  • Kraus MD, Bartlett NL, Fleming MD, Dorfman DM. Splenic pathology in myelodysplasia: a report of 13 cases with clinical correlation, Am J Surg Pathol 1998;22:1255–1266.
  • Haddad E, Sulis ML, Jabado N, Blanche S, Fischer A, Tardieu M. Frequency and severity of central nervous system lesions in hemophagocytic lymphohistiocytosis, Blood 1997;89:794–800.

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    Published: 2014-03-28
    Issue: Vol. 1 (2014) (view)

    How to cite:
    1.
    Quintero-Platt G, Belleyo-Belkasem C, Martín-Santos T, Pérez-Hernández O, González-Reimers E. Hemophagocytic Lymphohistiocytosis Complicating Myelodysplasia. EJCRIM 2014;1 doi:10.12890/2014_000016.