Behçet’s Disease and Tuberculosis: A Complex Relationship

  • Sara Mendonça Freitas Serviço de Medicina Interna, Hospital Beatriz Ângelo, Loures, Portugal
  • Joana Silva Marques Serviço de Medicina Interna, Hospital Beatriz Ângelo, Loures, Portugal
  • Ana Grilo Serviço de Medicina Interna, Hospital Beatriz Ângelo, Loures, Portugal
  • Rodolfo Gomes Serviço de Medicina Interna, Hospital Beatriz Ângelo, Loures, Portugal
  • Fernando Martos Gonçalves Serviço de Medicina Interna, Hospital Beatriz Ângelo, Loures, Portugal

Keywords

Cutaneous tuberculosis, Behçet’s disease, venous thrombosis

Abstract

Behçet’s disease (BD) is a systemic vasculitis characterized by recurrent orogenital ulceration and several systemic manifestations (such as gastrointestinal involvement, vascular disease or arthritis). The pathogenesis is still unknown but the trigger role of certain pathogens such as Mycobacterium tuberculosis is well documented. Furthermore, patients with BD are more susceptible to tuberculosis due to immunity defects. Here, we describe the case of a 70-year-old woman with a history of recurrent oral aphthae and inflammatory arthritis presenting with extensive thrombosis of left upper limb major veins, a positive HLA B51 genotype and colon ulceration; hence, BD diagnosis was made after excluding other causes. Simultaneously, the patient had cutaneous abscesses not associated with immunosuppressive therapy with continuous development, and after recurrent negative tuberculosis work-up, M. tuberculosis was isolated in an abscess culture.

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  • Published: 2020-01-16

    Issue: Vol 7 No 2 (view)

    Section: Articles

    How to cite:
    1.
    Freitas SM, Marques JS, Grilo A, Gomes R, Gonçalves FM. Behçet’s Disease and Tuberculosis: A Complex Relationship. EJCRIM 2020;7 doi:10.12890/2020_001354.

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