Systemic Amyloidosis with Renal Failure: A Challenging Diagnosis of SAPHO Syndrome
  • Cristina Pires Correia
    Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • António Martins
    Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • Jorge Oliveira
    Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • Sérgio Andrade
    Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal
  • Jorge Almeida
    Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal

Keywords

AA amyloidosis, SAPHO syndrome, hidradenitis suppurativa

Abstract

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare, unrecognized and chronic inflammatory disorder characterized by distinct cutaneous and osteoarticular manifestations. Renal complications are uncommon. We describe the unusual case of a patient with severe refractory and chronic hidradenitis suppurativa (HS) that progressed to chronic renal failure due to secondary amyloidosis, presenting with mandibular pain and renal failure. The challenging diagnosis of SAPHO syndrome was made. The purpose of this case report is to emphasize the need for vigilance, timely recognition and multidisciplinary treatment. The fundamental management of AA amyloidosis and SAPHO syndrome requires an individualized approach with control of the underlying inflammatory disease.

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References

  • Valentin R, Gurtler K, Schaker A. Renal amyloidosis and renal failure–a novel complication of the SAPHO syndrome. Nephrol Dial Transplant 1997;12:2420–2423.

  • Rukavina I. SAPHO syndrome: a review. J Child Orthop 2015;9:19.

  • Sasha D, Girouard BA, Rodney H, Falk MD, Helmut G, Rennke MD, et al. Hidradenitis suppurativa resulting in systemic amyloid A amyloidosis: a case report and review of the literature. Dermatol Online J 2012;18:2.

  • Firinu D, Garcia-Larsen V, Manconi PE, Del Giacco SR. SAPHO syndrome: current developments and approaches to clinical treatment. Curr Rheumatol Rep 2016;18:35.

  • Garcovich S, Amelia R, Magarelli N. Long-term treatment of severe SAPHO syndrome with adalimumab: case report and a review of the literature. Am J Clin Dermatol 2012;13:55.
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    Published: 2019-03-27
    Issue: Vol 6 No 4 (view)


    How to cite:
    1.
    Correia CP, Martins A, Oliveira J, Andrade S, Almeida J. Systemic Amyloidosis with Renal Failure: A Challenging Diagnosis of SAPHO Syndrome. EJCRIM 2019;6 doi:10.12890/2019_001087.

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