Metallosis: A New Form of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants Syndrome (ASIA)?

  • Rita Alexandra Vaz Department of Internal Medicine, Hospital São Francisco Xavier, Occidental Lisbon Hospital Centre, Portugal
  • Pedro Xavier Orthogeriatric Unit, Orthopedics and Traumatology Department, São Francisco Xavier Hospital, Occidental Lisbon Hospital Centre, Portugal
  • Sergio Brito Department of Internal Medicine, Hospital São Francisco Xavier, Occidental Lisbon Hospital Centre, Portugal
  • Jorge Dantas Department of Internal Medicine, Hospital São Francisco Xavier, Occidental Lisbon Hospital Centre, Portugal
  • Sofia Duque Orthogeriatric Unit, Internal Medicine Department, São Francisco Xavier Hospital, Occidental Lisbon Hospital Centre, Portugal
  • Jose Guimarães Consciência Orthogeriatric Unit, Orthopedics and Traumatology Department, São Francisco Xavier Hospital, Occidental Lisbon Hospital Centre, Portugal
  • Luis Campos Department of Internal Medicine, Hospital São Francisco Xavier, Occidental Lisbon Hospital Centre, Portugal

Keywords

ASIA syndrome, metallosis

Abstract

Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response. Metallosis is a rare condition characterized by the deposition and build-up of metal debris in the soft tissues of the body associated with metal-on-metal (MOM) prosthetic devices. It can present with local/systemic symptoms and signs due to a chronic inflammatory host response. The authors present the case of a 51-year-old woman with a 6-month history of systemic complaints due to intoxication with metal ions from hip metallosis. This case highlights the importance of follow-up and continuous monitoring of patients with a hip prosthesis. As this is a rare condition, a patient presenting with unspecific symptoms such as ASIA syndrome induced by metallosis requires a high level of clinical suspicion as the removal of the adjuvant can resolve the condition.

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  • Published: 2019-02-25

    Issue: LATEST ONLINE (view)

    Section: Articles

    How to cite:
    Vaz, R., Xavier, P., Brito, S., Dantas, J., Duque, S., Consciência, J., & Campos, L. (2019). Metallosis: A New Form of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants Syndrome (ASIA)?. European Journal of Case Reports in Internal Medicine, 2. https://doi.org/https://doi.org/10.12890/2019_001034