Severe Acquired Coagulopathy During Fulminant Staphylococcus aureus Sepsis Most Likely Caused by S. aureus Exotoxins (SSLs)

  • Lonneke Draaijers Rijnstate Arnhem
  • Robert-Jan Hassing Internal Medicine, Infectious Diseases, Rijnstate Hospital Arnhem, The Netherlands
  • Menno Kooistra Internal Medicine, Nephrology, Rijnstate Hospital Arnhem, The Netherlands
  • KoK van Kessel Medical Microbiology, University Medical Center Utrecht, The Netherlands
  • Marcel Hovens Internal Medicine, Vascular Medicine, Rijnstate Hospital Arnhem, The Netherlands

Keywords

Staphylococcus aureus, coagulopathy, staphylococcal superantigen-like protein, coagulation factor Xa, disseminated intravascular coagulation

Abstract

Haemostatic abnormalities frequently occur during sepsis and are most often attributed to disseminated intravascular coagulation (DIC). We report the case of a patient with severe coagulopathy acquired during fulminant S. aureus sepsis. DIC was not present. This coagulopathy was most likely caused by S. aureus exotoxins forming inhibitory complexes with coagulation factor Xa.

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  • Published: 2018-12-27

    Issue: Vol 5 No 12 (view)

    Section: Articles

    How to cite:
    Draaijers, L., Hassing, R.-J., Kooistra, M., van Kessel, K., & Hovens, M. (2018). Severe Acquired Coagulopathy During Fulminant Staphylococcus aureus Sepsis Most Likely Caused by S. aureus Exotoxins (SSLs). European Journal of Case Reports in Internal Medicine, 5(12). https://doi.org/https://doi.org/10.12890/2018_001002