Long Term Therapy with Lenalidomide in a patient with POEMS Syndrome
  • Benjamin Chu
    Division of Hematology, Department of Internal Medicine, Ohio State University
  • Arwa Shana'ah
    Department of Pathology, Ohio State University
  • Craig C Hofmeister
    Division of Hematology, Department of Internal Medicine, Ohio State University
  • Don M Benson
    Division of Hematology, Department of Internal Medicine, Ohio State University
  • Yvonne A Efebera
    Division of Hematology, Department of Internal Medicine, Ohio State University

Keywords

lenalidomide, POEMS

Abstract

Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating polyneuropathy was treated with lenalidomide and dexamethasone followed by maintenance lenalidomide. He remains in haematologic remission and in complete recovery of functional status 3.5 years after diagnosis. This case supports the long-term use of lenalidomide in patients with POEMS syndrome.

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    Published: 2014-10-22
    Issue: Vol. 1 (2014) (view)


    How to cite:
    1.
    Chu B, Shana’ah A, Hofmeister CC, Benson DM, Efebera YA. Long Term Therapy with Lenalidomide in a patient with POEMS Syndrome. EJCRIM 2014;1 doi:10.12890/2014_000093.