Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies
  • Tjitske Berends-De Vries
    Department of Intensive Care Medicine, Ziekenhuisgroep Twente, Almelo
  • Susan Boerma
    Department of Internal Medicine, Isala Klinieken, Zwolle
  • Joan Doornabal
    Department of Internal Medicine, Isala Klinieken, Zwolle
  • Bert Dikkeschei
    Department of Clinical Chemistry, Isala Klinieken, Zwolle
  • Coen Stegeman
    Department of Nephrology, University Hospital Groningen, Groningen
  • Thiemo Veneman
    Department of Intensive Care Medicine, Ziekenhuisgroep Twente, Almelo

Keywords

Goodpasture, diffuse alveolar hemorrhage, anti-GBM antibodies

Abstract

A young male patient with rapidly progressive and life-threatening pulmonary haemorrhage due to anti-glomerular basement membrane (anti-GBM) antibody disease without renal involvement repeatedly tested negative for serum anti-GBM antibodies. Although rare, anti-GBM antibody disease should be considered in the differential diagnosis in patients with life-threatening pulmonary haemorrhage due to isolated diffuse alveolar haemorrhage. Enzyme-linked-immunosorbent assay (ELISA) testing for anti-GBM antibodies in anti-GBM antibody disease can give false-negative results. A negative serum anti-GBM antibody test is therefore insufficient to exclude the diagnosis. Thus, a kidney or lung biopsy should be considered in any case with a high clinical suspicion but negative anti-GBM antibody test to confirm or rule out the diagnosis.

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    Published: 2017-10-30
    Issue: Vol. 4 No. 8 (view)

    How to cite:
    1.
    Berends-De Vries T, Boerma S, Doornabal J, Dikkeschei B, Stegeman C, Veneman T. Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies. EJCRIM 2017;4 doi:10.12890/2017_000687.