Purpura is Not Always Caused by the Anticoagulant
  • Catarina Maria Faria
    Department of Internal Medicine 2, Hospital de Leiria, Leiria
  • Fernando Henriques
    Department of Internal Medicine 2, Hospital de Leiria, Leiria
  • Jose Leite
    Department of Internal Medicine 2, Hospital de Leiria, Leiria
  • Celio Fernandes
    Department of Internal Medicine 2, Hospital de Leiria, Leiria

Keywords

Schamberg’s disease, amlodipine

Abstract

Pigmented purpuric dermatosis is a chronic benign skin disorder of unknown aetiology. Although there are several other potential cofactors, drugs are the most frequent cause. This paper describes the case of a 71-year-old woman who was admitted in the emergency department with skin lesions on the lower extremities, characteristics of Schamberg's disease. After a medical study and treatment, it was concluded that the lesions were caused by amlodipine administration. To the authors’ knowledge, only one previous case describing an association between this disease and amlodipine administration has been reported in the medical literature.

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References

  • Sardana K, Sarkar R, Sehgal VN. Pigmented purpuric dermatoses: an overview. Int J Dermatol 2004;43:482–488.
  • Tristani-Firouzi P, Meadows KP, Vanderhooft S. Pigmented purpuric eruptions of childhood: a series of cases and review of literature. Pediatr Dermatol 2001;18:299–304.
  • Torrelo A, Requena C, Mediero IG, Zambrano A. Schamberg's purpura in children: a review of 13 cases. J Am Acad Dermatol 2003;48:31–33.
  • Schetz D, Kocic I. A new adverse drug reaction – Schamberg´s disease caused by amlodipine administration – a case report. Br J Clin Pharmacol 2015;80:1477–1478.
  • Schamberg J. Report of three cases of progressive pigmentary dermatoses with particular reference to the blood cholesterol. Br J Dermatol 1927;39:389–393.
  • Schober SM, Peitsch WK, Bonsmann G, Metze D, Thomas K, Goerge T, Luger TA, Schneider SW. Early treatment with rutoside and ascorbic acid is highly effective for progressive pigmented purpuric dermatosis. J Dtsch Dermatol Ges 2014;12:1112–1119.
  • Newton RC, Raimer SS. Pigmented purpuric eruptions. Dermatol Clin 1985;3:165–169.
  • Dowd PM, Champion RH. Purpura. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Textbook of dermatology, 6th edn. Vol. 3. Oxford: Blackwell Scientific Publications; 1998; pp. 2141–2154.
  • Taketuchi Y, Chinen T, Ichikawa Y, et al. Two cases of unilateral pigmented purpuric dermatosis. J Dermatol 2001;28:493–498.
  • Wong WK, Ratnam KV. A report of two cases of pigmented purpuric dermatoses treated with PUVA therapy. Acta Derm Venereol 1991;71:68– 70.
  • Tamaki K, Yasaka N, Osada A, et al. Successful treatment of pigmented purpuric dermatosis with griseofulvin. Br J Dermatol 1995;132:159–160.
  • Wahba-Yahav AV. Schamberg’s purpura: association with persistent hepatitis B surface antigenemia and treatment with pentoxifylline. Cutis 1994;54:205–206.
  • Kano T, Hirayama K, Orihara M, Shiohara T. Successful treatment of Schamberg’s disease with pentoxifylline. J Am Acad Dermatol 1997;36:827–830.
  • Okada K, Ishikawa O, Miyachi Y. Purpura pigmentosa chronica successfully treated with oral cyclosporin A [letter]. Br J Dermatol 1996;134:180–181.
  • Rheinhold U. Treatment of progressive pigmented purpura with oral bioflavanoids and ascorbic acid: an open pilot study in 3 patients. J Am Acad Dermatol 1999;41:20.
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    Published: 2017-04-27
    Issue: Vol. 4 No. 3 (view)


    How to cite:
    1.
    Faria CM, Henriques F, Leite J, Fernandes C. Purpura is Not Always Caused by the Anticoagulant. EJCRIM 2017;4 doi:10.12890/2017_000536.