TAFRO Syndrome in a Patient of South-American Descent
  • Paola Finocchietto
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Damián Contardo
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Tatiana Uehara
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Claudia Papini
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Natalia Deligiannis
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Enrique Darderes
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Augusto Castroagudin
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Cecilia Cabral
    Department of Pathology, Hospital de Clínicas José de San Martín, University of Buenos Aires
  • Horacio di Fonzo
    Department of Internal Medicine, Hospital de Clínicas José de San Martín, University of Buenos Aires

Keywords

Castleman disease, TAFRO syndrome

Abstract

A 31-year-old Caucasian woman of South-American descent was diagnosed with a variant of multicentric Castleman disease (MCD) that has been reported in Japan as Castleman-Kojima disease. This is a systemic inflammatory disorder known as TAFRO Syndrome which includes thrombocytopenia, polyserositis (ascites/pleural effusion), microcytic anemia, myelofibrosis, fever, renal dysfunction and organomegaly, with immunologic disorder, polyclonal hypergammaglobulinemia, and elevated levels of interleukin-6 (IL-6) and the vascular endothelial growth factor present in serum and/or effusions. Optimal therapies are not well established. The patient was treated with methylprednisolone and rituximab. Following the start of treatment, the patient has been asymptomatic for over 8 months.

This is one of only a few reports of TAFRO Syndrome in a non-Japanese patient.

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    Published: 2015-07-14
    Issue: Vol. 2 No. 4 (2015) (view)


    How to cite:
    1.
    Finocchietto P, Contardo D, Uehara T, Papini C, Deligiannis N, Darderes E, Castroagudin A, Cabral C, di Fonzo H. TAFRO Syndrome in a Patient of South-American Descent. EJCRIM 2015;2 doi:10.12890/000220.